supramolecular

Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications.

4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide is a sulfonamide derivative used in the synthesis of building blocks for various supramolecular structures such as metal-organic skeletons and coordination polymers. It has antiproliferative activity against a variety of tumor cell lines.

Lipid N2-3L is an ionizable cationic lipid with a pKa of 8.99, utilized in the formation of supramolecular lipid nanoparticles (SMLNPs) for enclosing mRNA in both in vitro and in vivo applications. Lipid N2-3L-containing SMLNPs accumulate at the injection site and draining lymph nodes in mice, featuring a luciferase reporter gene. Additionally, SMLNPs made with Lipid N2-3L that encapsulate ovalbumin mRNA and the Toll-like receptor 7/8 (TLR7/8) agonist R-848 serve as adjuvants. These enhance dendritic cell maturation and antigen presentation, reducing tumor volume and increasing survival rates in MC-38-OVA colon cancer mouse models.

YZN62564, also known as meso-Tetra(2,6-dimethoxyphenyl) porphine, is a synthetic porphyrin compound with supramolecular characteristics. With Fe and Mn as central atoms, YZN62564 serves as a catalyst for various epoxidation and hydroxylation reactions.

5,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin is a porphyrin derivative capable of forming complexes with metal ions such as zinc (Zn), copper (Cu), and cadmium (Cd). These metal complexes exhibit phototoxicity towards Hep-2 cells, causing cell inactivation through the generation of singlet oxygen.

Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.

Fmoc-Phe(4-NH2)-OH (Fmoc-4-Amino-L-phenylalanine) is a phenylalanine derivative used in supramolecular hydrogel research.

Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin. It acts by disrupting the bacterial cytoplasmic membrane and inhibiting biofilm formation. Additionally, it binds to human serum albumin (HSA) with a dissociation constant (Kd) of 13.2 μM, enhancing its bactericidal activity. This compound also forms a supramolecular complex with DNA, thereby hindering DNA replication [1].

Cyclo(Leu-Leu) is an efficient supramolecular catalyst.

d-KYFIL is a peptide-based biomaterial capable of stereocomplexing, and it is applicable for studies on the supramolecular assembly of hydrogel biomaterials.