supramolecular

4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide is a sulfonamide derivative used in the synthesis of building blocks for various supramolecular structures such as metal-organic skeletons and coordination polymers. It has antiproliferative activity against a variety of tumor cell lines.

Lipid N2-3L is an ionizable cationic lipid with a pKa of 8.99, utilized in the formation of supramolecular lipid nanoparticles (SMLNPs) for enclosing mRNA in both in vitro and in vivo applications. Lipid N2-3L-containing SMLNPs accumulate at the injection site and draining lymph nodes in mice, featuring a luciferase reporter gene. Additionally, SMLNPs made with Lipid N2-3L that encapsulate ovalbumin mRNA and the Toll-like receptor 7 8 (TLR7 8) agonist R-848 serve as adjuvants. These enhance dendritic cell maturation and antigen presentation, reducing tumor volume and increasing survival rates in MC-38-OVA colon cancer mouse models.

YZN62564, also known as meso-Tetra(2,6-dimethoxyphenyl) porphine, is a synthetic porphyrin compound with supramolecular characteristics. With Fe and Mn as central atoms, YZN62564 serves as a catalyst for various epoxidation and hydroxylation reactions.

meso-Tetra (4-methoxyphenyl) Porphine (PPN12783) is a synthetic porphyrin compound. It exhibits photodynamic effects and has demonstrated cytotoxicity against human cancer cells in research. PPN12783, combined with polystyrene, is used in the production of electrospun nanofiber membrane sensors. Furthermore, it is employed in constructing optically active porphyrin supramolecular assemblies through the air-water interface assembly process.

Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.

Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications.

Fmoc-Phe(4-NH2)-OH (Fmoc-4-Amino-L-phenylalanine) is a phenylalanine derivative used in supramolecular hydrogel research.

Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin. It acts by disrupting the bacterial cytoplasmic membrane and inhibiting biofilm formation. Additionally, it binds to human serum albumin (HSA) with a dissociation constant (Kd) of 13.2 μM, enhancing its bactericidal activity. This compound also forms a supramolecular complex with DNA, thereby hindering DNA replication [1].

Cyclo(Leu-Leu) is an efficient supramolecular catalyst.

d-KYFIL is a peptide-based biomaterial capable of stereocomplexing, and it is applicable for studies on the supramolecular assembly of hydrogel biomaterials.