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sr 142948

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  • Inhibitors & Agonists
    4
    TargetMol | Inhibitors_Agonists
SR 142948
T23386184162-64-9
SR 142948 is a neurotensin (NT) receptor antagonist.
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8-10 weeks
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SR 142948-C3-NHMe
T2047381613265-52-3
SR 142948-C3-NHMe is the methylated form of SR 142948.
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10-14 weeks
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SR 142948 dihydrochloride
T73677
SR 142948 dihydrochloride is a selective, orally active, non-peptide neurotensin receptor (NT) antagonist, featuring IC50 values of 1.19 nM, 0.32 nM, and 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. It effectively inhibits NT-induced inositol monophosphate formation in HT-29 cells (IC50 = 3.9 nM) and blocks NT-induced hypothermia, analgesia, and steering behavior in vivo. Furthermore, it demonstrates blood-brain barrier permeability, positioning it as a potential tool for psychiatric disorder research [1] [2].
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SR142948A
SR142948 HCl, SR 142948A, SR 142948 HCl
T28845184162-21-8
SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist capable of blocking hypothermia and analgesic effects induced by intracerebroventricular injection of NT, and capable of concentration- and volume-dependent blockade of NMDA-induced dopamine release.
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