sdh-in-1

SDH-IN-1 (compound 4i) is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 value of 4.53 μM, exhibiting strong antifungal properties against S. sclerotiorum with an EC50 value of 0.14 mg L [1].

SDH-IN-12 (compound 9b), a succinate dehydrogenase inhibitor, shows activity against S. sclerotiorum and C. arachidicola, with respective EC50 values of 0.97 and 2.07 μM. The compound demonstrates no significant herbicidal effects on monocotyledonous and dicotyledonous plants [1].

SDH-IN-13 (Compound 5IIIh), with an IC 50 of 13.7 μg mL, functions as an SDH inhibitor and exhibits antifungal properties [1].

SDH-IN-11 (compound A7), a succinate dehydrogenase (SDH) inhibitor, effectively curtails nematode feeding, reproduction, and egg hatching. It induces oxidative stress and intestinal damage in nematodes. Additionally, SDH-IN-11 impedes the enzymatic activity of SDH within these organisms [1].

SDH-IN-10 is a potent succinate dehydrogenase inhibitor (SDHI) that exhibits antifungal activity [1].

SDH-IN-18 (Compound 3a) is an inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 8.70 mg L. This compound disrupts fungal morphology and reproduction, demonstrating antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 values of 0.48 mg L and 1.4 mg L, respectively.

SDH-IN-17 (compound C32) is a flavonol derivative containing an acylhydrazone, serving as an effective succinate dehydrogenase (SDH) inhibitor with an IC50 of 8.42 μM. This compound can bind to the active site and form strong interactions with key residues of SDH. Additionally, it exhibits antifungal activity against Fusarium graminearum (EC50=0.170 μg mL). SDH-IN-17 disrupts normal fungal growth by compromising the structural integrity of the cell membrane and cellular respiration. The potential of SDH-IN-17 for plant disease control research is noteworthy.

SDH-IN-19 (compound A13) is a fungicide effective against Rhizoctonia solani, with an EC50 value of 0.83 μg mL. It is utilized in agricultural research for fungal resistance in crops.

CP-642931 (Sorbitol dehydrogenase-IN-1) is an orally active and highly potent sorbitol dehydrogenase inhibitor for the study of diabetes and cardiovascular disease.

Succinate dehydrogenase-IN-1 (Compound 34) acts as an inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 0.94 μM and a KD of 22.4 μM. This compound also demonstrates antifungal activity, with EC50 values against Rhizoctonia solani, Sclerotinia sclerotiorum, Monilinia fructicola, and Botrytis cinerea measured at 0.04 μM, 1.13 μM, 1.61 μM, and 1.21 μM, respectively.

Penflufen, a broad-spectrum succinate dehydrogenase inhibitor (SDHI), serves effectively as a fungicide. It demonstrates broad bioactivity against a variety of fungal diseases such as potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanuts, among others [1].

Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes. 1.López-Martín, C., Pérez-Victoria, J.M., Carvalho, L., et al.Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomesAntimicrob. Agents Chemother.52(11)4030-4036(2008) 2.Carvalho, L.J.M., Luque-Ortega, J.R., López-Martín, C., et al.The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenaseAntimicrob. Agents Chemother.55(9)4204-4210(2011)

SDH-IN-4 (compound B6) is a selective succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.28 µg mL, demonstrating potent antifungal effects, including an EC50 of 0.23 µg mL against R. solani [1].

SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with potent antifungal activity, demonstrating an inhibition concentration (IC50) of 7.2 μg mL and an effective concentration (EC50) of 1.9 μg mL against Nigrospora oryzae, making it valuable for anti-infection research [1].

SDH-IN-6 (compound 6i), a potent inhibitor of succinate dehydrogenase (SDH), exhibits antifungal efficacy against Valsa mali, demonstrated by an EC50 value of 1.77 mg L [1].

SDH-IN-7 (compound G28) is a potent inhibitor of succinate dehydrogenase (SDH) with an IC50 value of 26 nM against porcine SDH and possesses fungicidal properties [1].

SDH-IN-9 (compound Ip) is a potent Succinate Dehydrogenase inhibitor with fungicidal properties, effectively targeting Fusarium graminearum Schw at an EC50 of 0.93 μg mL [1].

SDH-IN-5 (compound 7d), a potent inhibitor of succinate dehydrogenase (SDH) with an IC50 of 3.293 μM, additionally demonstrates antifungal efficacy, exhibiting an EC50 of 0.046 μg mL against R. solani. Moreover, SDH-IN-5 significantly hampers R. solani growth in rice leaves, showcasing outstanding protective and curative effects [1].

Benzovindiflupyr is a fungicide.1It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH; IC50= 5.2 nM), and mycelial growth ofS. sclerotiorum(EC50= 0.011 μg/ml). Benzovindiflupyr (60 μg/ml) completely protects eggplant leaves fromS. sclerotioruminfection. Formulations containing benzovindiflupyr have been used to control various fungal diseases in agriculture. 1.Gao, Y., He, L., Zhu, J., et al.The relationship between features enabling SDHI fungicide binding to the Sc-Sdh complex and its inhibitory activity against Sclerotinia sclerotiorumPest Manag. Sci.76(8)2799-2808(2020)

SDH-IN-8 (compound G40) is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 27 nM against porcine SDH and exhibits fungicidal properties [1].