r 065824

Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.

Nebivolol, a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect, is used in treatment of hypertension, in Europe, it is also used for left ventricular failure. It is highly cardioselective under certain circumstances.

(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol, a selective β1-adrenergic receptor antagonist (IC50 = 0.8 nM). Nebivolol exhibits vasodilatory activity and can prevent Nox2 NADPH oxidase up-regulation and lipoperoxidation in early stages of ethanol-induced cardiac toxicity.

Nebivolol hydrochloride (Standard) is the standard substance of Nebivolol hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.