purine

Purine (7H-Imidazo(4,5-d)pyrimidine) is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Two of the bases in nucleic acids, adenine and guanine, are purines. Purines from food (or from tissue turnover) are metabolised by several enzymes, including xanthine oxidase, into uric acid. High levels of uric acid can predispose to gout when the acid crystalises in joints; this phenomenon only happens in humans and some animal species (e.g. dogs) that lack an intrinsic uricase enzyme that can further degrade uric acid.

Adenine is a purine-derived nucleobase and one of the four bases of DNA. It is an important chemical component of both DNA and RNA, involved in cellular respiration, the formation of ATP and coenzymes NAD and FAD, as well as protein synthesis. Adenine is commonly used to induce chronic kidney injury models.

Adenine hydrochloride is a purine nucleobase and a chemical component of DNA and RNA. It is involved in cellular respiration, protein synthesis, and plays an important role in energy metabolism through high-energy molecules such as ATP, NAD, and FAD. It can be used to induce hyperuricemia and chronic kidney injury models.

Adenine hemisulfate is a purine-based nucleobase and an essential chemical component of DNA and RNA. It plays a key role in cellular respiration, the formation of ATP and coenzymes such as NAD and FAD, as well as in protein synthesis. It is commonly used to induce animal models of chronic liver and kidney injury and hyperuricemia.

Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and stress response genes, consistent with

Bohemine is a cyclin-dependent kinase inhibitor.

Xanthosine 5'-monophosphate sodium salt (L-XMP Sodium) serves as an intermediate in purine metabolism.

Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia

9H-purine,6-(1-pyrrolidinyl)- ,with CAS No. 1928-89-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 9H-purine,6-(1-pyrrolidinyl)- provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Purine riboside-5'-O-triphosphate sodium is an active metabolite of Nebularine and acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM, respectively. It also inhibits calmodulin-dependent protein kinase II (CaMKII), with a Ki value of 590 µM.

Purine riboside triphosphate, a derivative of purine riboside, exhibits structural similarity to adenosine. This naturally occurring base analog possesses inhibitory effects on carcinogenic growth, particularly in cancer ascites cells, by strongly impeding RNA and DNA synthesis.

Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of Plasmodium falciparum (Pf), Plasmodium vivax (Pv), and Trypanosoma brucei (Tbr) 6-oxopurine phosphoribosyltransferase (PRT) with Ki values of 30, 20, and 2 nM, respectively.

2-Methoxy-1,7,9-trimethyl-7,9-dihydro-1H-purine-6,8-dione is a useful organic compound for research related to life sciences and the catalog number is T64613.

8-Bromo-3-methyl-1H-purine-2,6(3H,7H)-dione is a useful organic compound for research related to life sciences. The catalog number is T65626 and the CAS number is 93703-24-3.

8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione is a useful organic compound for research related to life sciences. The catalog number is T66320 and the CAS number is 853029-57-9.

2-Amino-6-O-methyl-2'-O-methyl purine riboside, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include inhibition of DNA synthesis and induction of apoptosis, among others [1].

6-Methoxy-9-beta-D-(2-C-ethynyl-ribofuranosyl) purine is a purine nucleoside analog with broad antitumor activity targeting indolent lymphoid malignancies. Its anticancer mechanisms include inhibition of DNA synthesis and induction of apoptosis [1].

Purine Nucleoside Phosphorylase, an essential enzyme in purine metabolism, plays a critical role in the purine salvage pathway. Its deficiency impairs T cell function. With inorganic orthophosphate as a co-substrate, this enzyme catalyzes the cleavage of the glycosidic bond linking ribose and deoxyribonucleoside, resulting in the production of a purine base and ribose (deoxyribose)-1-phosphate [1].

6-(Methylthio)purine (Standard) is a reference standard for research and analysis in studies involving 6-(Methylthio)purine. 6-(Methylthio)purine is a useful organic compound for research related to life sciences. The catalog number is T64944 and the CAS number is 50-66-8.

1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

Nucleoside Derivatives - Fluoro-modified nucleosides, 3'-Modified nucleosides,6-Modified purine nucleosides

6-(Furan-2-yl)purine-beta-D-riboside is a Nucleoside Derivative - 6-Modified purine nucleoside.

Nucleoside Derivatives - Fluoro-modified nucleosides; 6-Modified purine nucleosides, 3'-Modified nucleosides

9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(thiophen-3-yl)purine is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purine nucleoside, 3'-Modified nucleoside.