ptp-1b-in-2

PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).

PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.

IONIS PTP1BRx (ISIS 404173) sodium, an antisense inhibitor of protein tyrene phosphatase 1B (PTP-1B), exhibits antidiabetic properties. This compound is utilzed in researching insulin resistance and type 2 diabetes mellitus associated with obesity.

PTP1B-IN-26 (compound 7a) is a derivative of phenylthiourea-semicarbazone-aryloxy-1,2,3-triazolyl-N-phenylacetamide. It acts as a competitive inhibitor of protein tyrosine phosphatase 1B (PTP-1B) and is applicable in type 2 diabetes research.

PTP1B/AKR1B1-IN-1 is a dual inhibitor targeting protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC50s of 0.06 μM for PTP1B and 4.3 μM for AKR1B1. It also inhibits T-cell protein tyrosine phosphatase (TC-PTP) with an IC50 of 9 μM. This compound acts as an insulin-mimetic in murine myoblasts, reduces AKR1B1-mediated sorbitol accumulation, and aids in managing blood glucose levels and inhibiting type 2 diabetes mellitus (T2DM) development [1].