protac smarca2 degrader-32

PROTAC SMARCA2 degrader-32 (Compound 27) is an effective degrader of SMARCA2, with a DC50 of 1.3 nM. It inhibits the proliferation of lung cancer cells NCI-H838 with a GI50 of 34 nM.

PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting both SMARCA2 and SMARCA4 proteins. In A549 cells, it shows DC50s values for the degradation of SMARCA2/4 proteins <100 nM and achieves a maximum degradation rate (Dmax%) of >90 after 24 hours of treatment.

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.

E3 Ligase Ligand-linker Conjugate 150 is a conjugate consisting of a ligand for the E3 ligase VHL and a linker, and it is utilized in the synthesis of PROTAC SMARCA2 degrader-32.

(S)-(S,R,S,R)-AHPC-Me-N3 is an E3 ligase ligand for PROTACSMARCA2 degrader-32, utilized in the synthesis of PROTACs.

SMARCA2 ligand-11 is a ligand for SMARCA2 and can be utilized as a target protein ligand in the synthesis of the PROTAC SMARCA2 degrader-32.