pop

Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor. Salidroside can alleviate cachexia symptoms in a tumor cachexia mouse model by activating mTOR signaling and protect dopaminergic neurons by enhancing PINK1/Parkin-mediated mitochondrial autophagy. Salidroside can also inhibit the growth of cancer cells by regulating the CDK4-cyclin D1 pathway to block the G1 phase and/or regulating the Cdc2-cyclin B1 pathway to block the G2 phase.

β-Elemonic Acid (3-Oxotirucallenoic Acid) exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells. Beta-Elemonic acid exhibits prolyl endopeptidase inhibitory activities.

Oroxylin A 7-O-β-d-glucuronide and wogonoside should also be served as the chemical markers together with baicalin for the quality control of herbs and proprietary traditional Chinese medicine (PTCM) products of radix Scutellariae. Oroxylin A 7-O-glucuronide, Oroxin A, and Oroxin B can bind to the stem region of α-hemolysin (α-HL), when inhibiting the hemolytic activity of α-HL. Oroxylin A 7-O-glucuronide and 4', 5, 7-trihydroxy-6-methoxyflavone at a concentration of 100 microM inhibit 34 and 43% of total prolyl oligopeptidase (POP) activity, respectively.

Linderene acetate is a competitive inhibitor against Prolyl endopeptidase.

Lipopolysaccharides (LPS), derived from Escherichia coli O55:B5, are essential components of the outer membrane of Gram-negative bacteria. Composed of lipid A, a core oligosaccharide, and an O-specific polysaccharide, LPS exhibits strong immunogenicity. It activates immune cells via the TLR4 receptor, induces chemotactic cell migration and cytokine secretion, and helps maintain the integrity of the bacterial outer membrane, protecting against bile salts and lipid-based antibiotics. LPS is commonly used to establish inflammatory models, including arthritis, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), and gastrointestinal disease models.

Populin (Populine) is a phenolic glycoside compound derived from ciliated poplar with antioxidant activity.

Populoside is a useful organic compound for research related to life sciences. The catalog number is T125159 and the CAS number is 26632-35-9.

Poppy acid is a useful organic compound for research related to life sciences and the catalog number is T131392.

Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 μM). Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells. It also has antibiotic and antifungal actions.

Lipopolysaccharides from Escherichia coli O111:B4 are key components of the outer membrane of Gram-negative bacteria. As a smooth-type LPS, they consist of lipid A, an R3-type core oligosaccharide, and an O-specific polysaccharide. These LPS molecules exhibit high immunogenicity, can trigger strong immune responses and gastric disorders by activating the TLR-4 receptor on immune cells, and help maintain the structural integrity of the bacterial outer membrane while protecting against bile salts and lipid-based antibiotics. They are widely used to establish inflammation-related disease models, such as chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS).

Apoptosis Inducer 5, a lignan enantiomer extracted from Crataegus pinnatifida, demonstrates cytotoxic properties through inducing apoptosis and autophagy in Hep3B cells.

Lipoprotein lipase (LPL) is an enzyme, mainly involved in lipid metabolism, that hydrolyzes triglycerides in lipoproteins.LPL can be a target for obesity/diabetes-related cardiovascular diseases and has an important role in lowering triglyceride levels and improving cardiovascular.

β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage, cell cycle arrest, and ER stress. This compound holds potential for cancer research applications [1].

POPE(1-Palmitoyl-2-oleoyl-sn-glycero-3-PE) is a compound found in Escherichia coli, part of the cell membrane, and can be used to study changes in cell membrane permeability.

Epopromycin A inhibits the cell wall synthesis of lettuce protoplasts, demonstrating herbicidal activity. In B16 melanoma cells, Epopromycin A exhibits cytotoxicity with an IC50 of 0.003 µg/mL.

Epopromycin B inhibits cell wall synthesis in lettuce protoplasts, demonstrating herbicidal activity. It also exhibits cytotoxicity in B16 melanoma cells, with an IC50 of 0.003 µg/mL.

Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.

POPi (phloridzin oxidation product i) is a colorless oxidation product of phloridzin, catalyzed by apple polyphenol oxidase, with DPPH radical scavenging activity. It is utilized in antioxidant research.

PANEPOPHENANTHRIN is a metabolite of Panapophenanthrin, derived from a novel oligocyclic diterpenoid isolated from Panus strigellus. PANEPOPHENANTHRIN has the ability to inhibit ubiquitin-activating enzyme.

Apopinene is a compound found in certain plants, particularly the toxic Aconitum genus, also known as monkshood or wolfsbane. This compound exhibits potent neurotoxicity and has historically been used as a poison. However, with great caution, it has also been employed as a medicinal herb.

2-Bromobiphenyl is a persistent organic pollutant (POP) found primarily in soil and water. It is a known human carcinogen and has been linked to a variety of health effects including reproductive and developmental toxicity.

Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentrations ranging from 0.1 microm to 10 microm.