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Results for "
phototrexate
" in TargetMol Product Catalog- Inhibitors & Agonists2
Phototrexate
T411482268033-83-4In house
Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark.cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared withtrans-Phototrexate (IC50 = 34 μM).
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trans-Phototrexate
azoMTX
T2019652412518-81-9
trans-Phototrexate acts as an inhibitor of Escherichia coli dihydrofolate reductase (eDHFR), enabling wavelength-dependent photoreversible control of this enzyme.
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