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Results for "
nolatrexed dihydrochloride
" in TargetMol Product Catalog- Inhibitors & Agonists1
Nolatrexed dihydrochloride
Thymitaq, AG 337
T2627152946-68-4
Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
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T4228147149-76-6
Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
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