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nms249

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PNU-159682
T16557202350-68-3
PNU-159682, a metabolite of anthracycline nemorubicin, is a DNA topoisomerase II inhibitor with excellent cytotoxicity.
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Mal-VC-PAB-DMEA-PNU-159682
SET0568, Mal-VC-PAB-DMEA-PNU-159682
T2043031178887-17-6
Mal-VC-PAB-DMEA-PNU-159682 is an agent-linker conjugate for ADCs, designed by linking the topoisomerase II inhibitor PNU-159682 with the lysosomally cleavable dipeptide Mc-VC-PAB, demonstrating potent antitumor activity. Additionally, Mal-VC-PAB-DMEA-PNU-159682 can be utilized for the synthesis of Anti-CD22-NMS249.
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