nh-2-peg3

NH2-PEG3 (PROTAC Linker 35) is a polyethylene glycol (PEG) linker used in the synthesis of PROTAC (β-NF-JQ1)[1].

NH2-PEG3 hydrochloride is a PEG-based linker for PROTACs, crucial for joining two essential ligands to form PROTAC molecules. This compound facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

NH2-PEG3-C1-Boc is a PEG-based PROTAC linker that can be used for the synthesis of PROTAC molecules.

Amino-PEG3-t-butyl ester is a PEG derivative containing an amino group with the t-butyl protected carboxyl group. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

NH2-PEG3-C6-Cl, a PEG-based linker for PROTACs, connects two essential ligands critical for forming PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

NH2-PEG3500-NH2 is a PROTAC linker belonging to the PEG category, utilized in synthesizing PROTAC molecules.

NH2-PEG3-VC-PAB-MMAE is a drug-linker conjugate for ADC, which combines a cleavable ADC linker (NH2-PEG3-VC-PAB) with a potent tubulin inhibitor Monomethylauristatin E (MMAE). It is mainly used in the synthesis of antibody-drug conjugates (ADCs).

NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC (antibody-drug conjugate) linker characterized by a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on PAB facilitates conjugation with reactive groups like PNP, enabling attachment to drug payloads. The primary amine readily participates in various reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, and other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular proteases, allowing efficient payload delivery through an elimination mechanism within the PAB structure.

Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) is an E3 ligase ligand-linker conjugate.

Ald-Ph-amido-C2-PEG3-NH-Boc is a polyethylene glycol (PEG)-based bifunctional linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a seven-unit cleavable polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker used in ADC synthesis[1].

Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a polyethylene glycol (PEG)-based linker used in synthesizing PROTACs, aiding in the targeted degradation of specific proteins [1].

2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc is the PD-L1 ligand-linker polymer of AUTACPD-L1degrader-3. It can be utilized in the synthesis of AUTAC.

PT-129 is a PROTAC degrader targeting the NTF2 domain of G3BP1/2, capable of inhibiting and degrading stress granules in stressed cells, disrupting ATF4 trafficking, and suppressing fibroblast-mediated cancer cell proliferation.

Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized conjugate functioning as an E3 ligase ligand-linker, incorporating the cereblon ligand derived from Thalidomide and a linker, and is utilized in the synthesis of PROTAC BET degraders.