ng 26

CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.

TNG260 is a selective and orally effective inhibitor of HDAC1 and the CoREST complex, exhibiting 10-fold selectivity for HDAC1 over HDAC3 and 500-fold selectivity for CoREST over NuRD and Sin3 complexes. TNG260 reshapes the tumor immune microenvironment by reducing immunosuppressive neutrophil infiltration, enhancing effector T-cell recruitment, reversing anti-PD-1 resistance driven by STK11 deficiency, and inducing durable tumor regression in combination with α-PD-1 in STK11-mutant MC38 tumor models while maintaining lower bone marrow toxicity than non-selective HDAC inhibitors.

Telinavir (SC-52151) is a potent and selective inhibitor of HIV protease. It effectively inhibits both HIV-1 and HIV-2, as well as lymphotropic, monocytotropic strains, and wild isolates of simian immunodeficiency viruses, with an EC50 of 26 ng/mL (43 nM). Telinavir shows high protein binding in human plasma and a low distribution rate in red blood cells.

7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits growth of the mycelial, but not yeast form of C. albicans, C. krusei, C. tropicalis, and C. lusitaniae (MICs = 3.1-25 μg/ml). It increases sphingomyelin synthesis in CHO-K1 cells when used at a concentration of 50 nM.