neuroleptics

L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM, and considerably weaker D2 receptor affinity with a Ki of 960 nM and D3 receptor affinity with a Ki of 2300 nM. 

Preclamol hydrochloride ((-)-3-PPP hydrochloride) is a selective dopamine autoreceptor agonist. It functions by specifically activating presynaptic autoreceptors, which triggers a negative feedback loop to inhibit the synthesis and release of dopamine. Unlike conventional neuroleptics that primarily block postsynaptic receptors, Preclamol offers a more refined modulation of the dopaminergic system. This unique pharmacological profile makes it a valuable tool in schizophrenia research, aiming to alleviate psychotic symptoms with a potentially lower risk of extrapyramidal side effects.