ml-213

ML213 (CID-3111211) is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.

G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic that selectively inhibits eukaryotic protein synthesis by blocking peptide chain elongation.

Antibacterial agent 213 (compound Thy3d) exhibits antibacterial activity by disrupting the integrity of bacterial membranes, with a minimum inhibitory concentration (MIC) of 0.5 μg/ml against Staphylococcus aureus (MRSA).

XOMA-213 (LFA-102; X213) is a human monoclonal antibody (mAb) that specifically targets the PRLR/Prolactin Receptor. It inhibits hPRL-dependent growth of BaF3/hPRLR cells with an EC50 of 0.5 μg/mL. In models such as the Nb2-11-luc xenograft mouse and the DMBA-induced rat breast cancer model, XOMA-213 effectively suppresses PRLR signaling and tumor growth. This compound is applicable in research focused on breast cancer, hyperprolactinemia, and prostate cancer.