mevalonate pathway

N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity. N6-Isopentenyladenosine, an RNA modification found in cytokinins, regulates plant growth/differentiation and improves the efficiency

DL-Mevalonolactone, a human endogenous metabolite, is the δ-lactone form of mevalonate, a precursor of the mevalonate pathway. It reduces mitochondrial membrane potential (∆Ψm), Ca2+ retention and NAD(P)H levels in the brain, and also induces mitochondrial swelling.DL-Mevalonolactone induces inflammation and oxidative stress, and reduces mitochondrial membrane potential.

Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol (FT0626663) inhibits growth and induces apoptosis of various tumor cells. Geranylgeraniol (FT0626663) protects monocytes against statin-induced cytotoxicity and suppresses the growth of Mycobacterium.

Farnesyl Pyrophosphate ammonium salt is an isomer of (E,E)-Farnesyl Pyrophosphate ammonium salt, which is a key metabolic intermediate in the mevalonate (MVA) pathway and an agonist of TRPM2, and is involved in cholesterol synthesis, ubiquinone synthesis, protein farnesylation and other physiological processes.

Mevalonic acid is essential for cell growth and proliferation,Mevalonic acid is a precursor in the mevalonate pathway.

Geranyl pyrophosphate is an intermediate in the mevalonate pathway. It is formed from dimethylallyl pyrophosphate and isopentenyl pyrophosphate by geranyl pyrophosphate synthase. Geranyl pyrophosphate is used in the biosynthesis of farnesyl pyrophosphate , geranylgeranyl pyrophosphate , cholesterol, terpenes, and terpenoids.

FR900098 is a derivative of fosmidomycin that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively). FR900098 inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, in vitro in a dose-dependent manner. FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice.

Mevalonic acid 5-pyrophosphate (also known as 5-Diphosphomevalonic acid) tetralithium is an endogenous metabolite involved in the mevalonate pathway.

DMAPP triammonium (Dimethylallyl diphosphate triammonium) is one of the prerequisite substances for an isoprenoid involved in the mevalonate (MVA) pathway, which can be used in the study of metabolism-related diseases.

Antimalarial agent 18, a powerful antimalarial compound characterized by its electronic, highly lipophilic, and siderophoric properties, falls within the acyloxymethyl series, acting as a fosmidomycin surrogate. It effectively inhibits the non-mevalonate isoprenoid biosynthesis pathway by targeting the IspC enzyme. This compound demonstrates significant inhibitory activity against P. falciparum (IC50 = 50 nM) and A. baumanii (IC50 = 390 nM).

Farnesyl pyrophosphate (Farnesyl diphosphate), a 15-carbon isoprenoid from the mevalonate (MVA) pathway, functions as a metabolic intermediary and TRPM2 (TRP Channel) agonist, facilitating TRPM2 channel opening and ion influx. It is crucial in synthesizing cholesterol, ubiquinones, and geranyl-geranyl pyrophosphate (GGPP), and in protein farnesylation decoration [1].

HMBPP lithium is an intermediate in isoprene biosynthesis, produced by bacteria and protozoa using the non-mevalonate pathway. It serves as a ligand for the inner domain of BTN3A1 and acts as an activator of human Vγ9/Vδ2T cells. Additionally, HMBPP lithium stimulates feeding behavior in mosquitoes.

2-C-Methyl-D-erythritol 4-phosphate is a unique metabolic intermediate exclusive to the non-mevalonate pathway (MEP) predominantly found in prokaryotes. It serves as a precursor for the synthesis of both isoprenoids and non-isoprenoids (including vitamins). Not present in humans, this compound represents a promising target for the development of bacterial-specific drugs for treating infectious diseases.

1-Deoxy-D-threo-pentulose is a derivative of D-xylulose with active applications in the study of the mevalonate pathway. This compound is extensively used to explore cellular metabolic mechanisms and holds significant experimental value in biochemical research.

Acetoacetyl CoA serves as a precursor to HMG-CoA in the mevalonate pathway. Catalyzed by acetoacetyl-CoA thiolase, it is formed from two acetyl-CoA molecules. Acetoacetyl CoA is vital for cholesterol biosynthesis and also acts as an intermediate in both the breakdown and synthesis of fatty acids.