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lly-283

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
LLY-283
T157672040291-27-6
LLY-283 is a potent, selective, and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, exhibiting an IC50 of 22 nM and a Kd of 6 nM for the PRMT5:MEP50 complex, and demonstrates antitumor activity.
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10-14 weeks
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LLY-284
T223562226515-75-7
LLY-284, the diastereomer of LLY-283, serves as a selective and potent SAM-competitive chemical probe for PRMT5. Unlike the highly active LLY-283, LLY-284 exhibits significantly lower activity and is used as a negative control for LLY-283.
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