kuwanon a

Kuwanon A inhibits nitric oxide production (IC50: 10.5 μM). Kuwanon A is a flavone derivative isolated from Morus alba L.

1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has anti-inflammatory activity, it can attenuate atherosclerosis through inhibiting foam cell formation and inflammatory response. 3. Kuwanon G is a potent inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B. 4. Kuwanon G shows acetylcholinesterase (AChE) and butyrylcholinesterase(BChE) inhibitory activities, it may be a promising candidate for preventive and therapeutic agents for Alzheimer's disease. 5. Kuwanon G prevents the pathological progression of allergic asthma through the inhibition of lung destruction by inflammation and immune stimulation. 6. Kuwanon G has antibacterial activity against oral pathogens. 7. Kuwanon G is a specific antagonist for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.

Kuwanon B belongs to the class of organic compounds known as 3-prenylated flavones. Within the cell, kuwanon B is primarily located in the membrane (predicted from logP). Outside of the human body, kuwanon b can be found in fruits. This makes kuwanon b a

Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophils. Cyclomorusin , neocyclomorusin

Kuwanon S is a natural flavonoid found in Morus alba that is used in organic synthesis and biochemical experiments.

Kuwanon K, a natural product, is extractable from Morus Lhou [1].

Kuwanon U (4'-methoxykuwanon E), a compound from Morus alba, is a cholinesterase inhibitor with antimicrobial activity, inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and exerts its inhibitory effect by preventing ATP binding in the cytoplasmic domain of SERCA1, which can be used in the study of diabetes mellitus and bacterial infections.

Kuwanon W, a natural product, is isolable from the root bark of Morus lhou [1].

Kuwanon H, and possibly kuwanon G also, are specific antagonists for the gastrin-releasing peptide (GRP) -preferring receptor and can be useful for studying the physiological and pathological role of GRP.

Kuwanon O, a flavonoid derivative featuring a fused dihydrochalcone segment, is extractable from the root bark of Morus lhou (set.) Koidz [1].

Kuwanon E, a flavonoid obtained from Morus alba, has potential anti-inflammatory activity, inhibits TNF-α and IL-1β secretion, and suppresses NF-κB nuclear translocation in LPS-stimulated macrophages.