isomer

INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.

Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.Eltanexor Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.

LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.

TTA-Q6 (isomer) is an isomer of TTA-Q6, which functions as a selective antagonist of the T-type Ca2+ channel.

NVP-BHG712 isomer shows conserved non-bonded binding to EPHA2 and EPHB4.

T3-ATA S-isomer, the S-isomer of T3-ATA, represents the active form of the thyroid hormone.

T4-ATA S-isomer, the active form of the thyroid hormone, represents the S-isomer of T4-ATA.

Ulevostinag isomer 2 (MK-1454 isomer 2) is an isomer of Ulevostinag, which acts as a STING agonist.

Ulevostinag (isomer 3) (example 246) is an effective stimulator of the STING (stimulator of interferon genes) pathway. It plays a significant role in anti-tumor research.

Ulevostinag isomer 4 (MK-1454 isomer 4) is an isomer of Ulevostinag, which functions as a STING agonist.

Edoxaban Isomer is an impurity of Edoxaban, which is a novel inhibitor of factor Xa.

Sotorasib (AMG-510) isomer is a less active isomer of Sotorasib (AMG-510), which is a potent covalent inhibitor of KRAS G12C.

BAY-598 R-isomer is the R-isomer of BAY589, which is used as a reference compound. It is is an inhibitor of lysine N-methyltransferase (SMYD2) and is selective for SMYD2 over protease-activated receptor 1 (PAR1).

Trichostatin A S-isomer is the s-isomer of Trichostatin A. Trichostatin A is a histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Trichostatin A inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20

AZD6482 (S-isomer) is a potent, selective, ATP-competitive PI3Kβ inhibitor (IC(50) 0.01 μm), which can inhibit insulin-induced in vitro glucose uptake by human adipocytes (IC(50) is 4.4 μm).

Midodrine is a vasopressor/antihypertensive agent for the treatment of symptomatic postural hypotension.

Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), a tamoxifen metabolite, is an effective and specific Estrogen Response Modifier (SERM).

SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 160 nM).

IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 S-isomer shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research.

ISRIB (trans-isomer) is a potent inhibitor of PERK (IC50=5 nM) that restores protein translation and prevents SG formation in the presence of P-eIF2α.

RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.

TIC10 Isomer (ONC201 isomer) is an isomer of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.

BAY-6035 is an inhibitor of the methylation of MEKK2 peptide.

MKC-963 is a platelet aggregation inhibitor and autoinducer of CYP3A4.