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By Target- Proteasome
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- cholecystokinin
- CRFR
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- Endothelin Receptor
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- Glucagon Receptor
- GNRH Receptor
- GPCR19
- GPR
- GRK
- GTPase
- Guanylate cyclase
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- Histamine Receptor
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- Leukotriene Receptor
- LPA Receptor
- LPL Receptor
- Melanin-concentrating Hormone Receptor (MCHR)
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Results for "
immunoproteasome β1c
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Natural Products1
UK-101
UK101, UK 101
T132471000313-40-5In house
UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM, respectively. UK-101 exhibits a 144-fold and 10-fold higher affinity for β1i than for the distribution of β1c and β5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer-related diseases.
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Argyrin B
TN9039174423-36-0
Argyrin B is a naturally occurring cyclic peptide that acts as a reversible non-competitive inhibitor of the immunoproteasome. It exhibits higher inhibitory selectivity for the β5i and β1i sites of the immunoproteasome compared to the β5c and β1c sites of the constitutive proteasome, being nearly 20 times more selective for β1i than for its homolog β1c. Additionally, Argyrin B possesses antibacterial properties.
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