idasanutlin

Idasanutlin (Ro 5503781) is a potent, highly selective small-molecule MDM2 inhibitor with an IC₅₀ value of 6 nM. Idasanutlin exerts its antitumor effects primarily by restoring the function of the p53 signaling pathway. Idasanutlin can be used in cancer treatment research.

Idasanutlinenantiomer is an isomer of Idasanutlin and can be used as a control compound in experiments. Idasanutlin (RG7388) is a potent and selective MDM2 antagonist that inhibits the interaction between p53 and MDM2, with an IC50 value of 6 nM.

PROTACHDAC8 Degrader-3 (Compound BP6) is an efficient and selective HDAC8PROTAC degrader with low cytotoxicity, exhibiting a DC50 of 80 nM. It demonstrates IC50 values of 0.26 μM for HDAC8 and 30 μM for CRBN. PROTACHDAC8 Degrader-3 enhances Ac-SMC3 levels, stabilizes p53, and sensitizes cells to targeted agents such as Idasanutlin, indicating significant potential for combination therapy.