hppd

HPPD-IN-3 (compound 25) serves as a potent inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD) and exhibits greater efficacy than Mesotrione, featuring an IC50 of 10 nM [1].

HPPD-IN-4 (Compound III-29) serves as a selective HPPD inhibitor, demonstrating an IC 50 value of 0.19 μM. It is primarily utilized in research focused on high-efficiency herbicides [1].

HPPD-IN-1 (compound II-3), a potent HPPD inhibitor, exhibits inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) with an IC50 of 0.248 μM, surpassing mesotrione's IC50 of 0.283 μM, and demonstrates excellent herbicidal efficacy against both broadleaf and monocotyledonous weeds [1].

AtHPPD-IN-1 (Compound III-15) is an HPPD inhibitor and herbicide with high safety for peanuts. It has an IC50 of 12 nM against Arabidopsis HPPD.

Mesotrione is a selective triketone herbicide

Sulcotrione is a β-triketone herbicide. It also can inhibit hydroxyphenylpyruvate dioxygenase.

Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (FAH) deficiency in mice when administered to pregnant dams.2It exhibits hepatoprotective effects inFAH-/-mice, such as prevention of increases in plasma levels of aspartate serine aminotransferase (AST) and conjugated bilirubin, when administration is continued following birth at a dose of 1 mg/kg. Nitisinone (100 μg) decreases urinary excretion of homogentisate and increases urinary excretion of HPPA, HPLA, and 4-hydroxyphenylacetate in a mouse model of alkaptonuria induced by ethylnitrosourea.3Formulations containing nitisinone have been used in the treatment of hereditary tyrosinemia type 1 (HT-1). 1.Ellis, M.K., Whitfield, A.C., Gowans, L.A., et al.Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dioneToxicol. Appl. Pharmacol.133(1)12-19(1995) 2.Grompe, M., Lindstedt, S., al-Dhalimy, M., et al.Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type INat. Genet.10(4)453-460(1995) 3.Suzuki, Y., Oda, K., Yoshikawa, Y., et al.A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuriaJ. Hum. Genet.44(2)79-84(1999)

Cypyrafluone is a dual oxidase inhibitor of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD), effectively blocking the production of homogentisic acid (HGA).

Fenquinotrione, a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, exhibits IC50 values of 27.2 and 44.7 nM against HPPD from rice and Arabidopsis thaliana, respectively. As an herbicide, it effectively controls a wide spectrum of broadleaf and sedge weeds while demonstrating notable selectivity for rice [1].

Topramezone, a highly effective 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor, functions as a herbicide for the post-emergence eradication of broadleaf and grass weeds in corn [1].

Brassicanate A sulfoxide, isolated from Brassica oleracea [1], exhibits herbicidal properties by inhibiting the biosynthesis of essential amino acids in plants. It operates by binding to key enzymes such as dihydroxyacid dehydratase (DHAD), hydroxymethylpyruvate dioxygenase (HPPD), acetolactate synthase (ALS), PYL family proteins, and transport inhibitor response 1 (TIR1), thereby reducing their enzymatic activity.

Benzobicyclon is a 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor and herbicide that is spectrally active against annual grasses, sedges, and broadleaf weeds without toxicity to rice.