h-gly-gly-gly-oh

H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of three glycine amino acids linked by peptide bonds. It is commonly utilized as a model compound in studies of protein structure and function. Glycylglycylglycine may also act as a neurotransmitter in the central nervous system and has demonstrated antioxidant properties. Furthermore, it holds potential research significance in various diseases, such as cancer, diabetes, and neurodegenerative disorders.

H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.1It inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets with IC50values of 320 and 35 μM, respectively.2Implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs.3H-Arg-Gly-Asp-Cys-OH has been conjugated to polyethylenimine to improve gene transfection efficiency.4 1.Park, H.S., Kim, C., and Kang, Y.K.Preferred conformations of RGDX tetrapeptides to inhibit the binding of fibrinogen to plateletsBiopolymers63(5)298-313(2002) 2.Tranqui, L., Andrieux, A., Hudry-Clergeon, G., et al.Differential structural requirements for fibrinogen binding to platelets and to endothelial cellsJ. Cell Biol.108(6)2519-2527(1989) 3.Ferris, D.M., Moodie, G.D., Dimond, P.M., et al.RGD-coated titanium implants stimulate increased bone formation in vivoBiomaterials20(23-24)2323-2331(1999) 4.Kunath, K., Merdan, T., Hegener, O., et al.Integrin targeting using RGD-PEI conjugates for in vitro gene transferJ. Gene Med.5(7)588-599(2003)

H-Gly-Pro-OH (Glycyl proline) is a dipeptide composed of glycine and proline, and is an end product of collagen metabolism

H-D-Leu-Gly-OH (CAS number 997-05-7, catalog number T65226) is a valuable organic compound utilized in life sciences research.

H-D-Gly(allyl)-OH is a valuable organic compound for life sciences research with catalog number T66526 and CAS number 54594-06-8.

H-Gly-Arg-Gly-Asp-Asn-Pro-OH (GRGDNP) is a integrin-ligand interactions inhibitor.

H-Arg-Gly-Tyr-Ala-Leu-Gly-OH is a competitive inhibitor of cAMP-dependent protein kinase [1].

H-Pro-Gly-Pro-OH, a collagen-derived matrikine, traditionally acts as a neutrophil chemoattractant, guiding these cells to target locations to orchestrate localized repair responses. Additionally, this compound initiates the transcription of neurotrophins and their receptor genes following cerebral ischemia [1] [2].

Phytochelatin 4 (PC 4) a glutathione derived peptide and heavy metal detoxifier/chelator consisting of 4 units of glu - cys and generated by PC synthase, is tolerant to Cd (cadmium) and is sequestered in vesicles after complexation with heavy metals.

H-Val-Thr-Cys-Gly-OH is a cell attachment peptide that promotes cell adhesion and facilitates various cell interactions [1].

H-Gly-Pro-Hyp-OH is a potent and orally available anti-photoaging collagen peptide that attenuates inflammation and reduces MMP-1 and MMP-3 levels; attenuates H2O2-induced aging of dermal fibroblasts; restores cortisol-mediated inhibition of type I collagen and GR activation and (TGF)-β signaling signaling, among other things; and improves the hydration of human skin, elasticity and anti-wrinkle properties.

GLF (H-Gly-Leu-Phe-OH), a tripeptide isolated from α-lactalbumin with immunostimulatory properties, prevents alopecia, epidermal thickening, and adipocyte layer thinning induced by the anticancer agent Etoposide [1].

[Leu144,Arg147]-PLP (139-151) is a mutated fragment of the myelin proteolipid protein (PLP), featuring substitutions of tryptophan to leucine and histidine to arginine at positions 144 and 147, respectively. Immunizing mice with this peptide (50 µg) mixed in complete Freund's adjuvant (CFA) elevates IL-4 levels in the spleen. While it suppresses Th1 cell activation in vitro, it does not do so in vivo; instead, it promotes the development of regulatory T cells. Preimmunization with [Leu144, Arg147]-PLP (139-151) postpones the onset of experimental autoimmune encephalomyelitis (EAE) triggered by encephalitogenic peptides from PLP (178-191), myelin oligodendrocyte glycoprotein (MOG) (92-106), or myelin basic protein (MBP) in mice.

H-(Gly)3-Lys(N3)-OH (hydrochloride) is a click chemistry reagent renowned for its high yield, specificity, and simplicity, making it an ideal choice for creating bindings among nucleic acids, lipids, proteins, and other molecules across various research domains.

H-Gly-Pro-Hyp-OH, a peptide dipeptidyl peptidase 4 (DPP-4) inhibitor with an inhibition concentration (IC50) of 2.51 mM, effectively hinders the activity of the DPP-4 enzyme.

H-Asp-Gly-OH is a cleavable ADC linker.

H-(Gly)3-Lys(N3)-OH is a chemical reagent featuring an azide group prominently used in click chemistry for coupling with alkyne-containing fragments. Azides are extensively utilized for this purpose due to their effectiveness in such reactions. A polyglycine segment containing up to seven glycine residues has been reported to bind to surfaces, demonstrating potential applications in nanostructures; specifically, the Gly7-NHCH2 peptide segment binds to mica surfaces in aqueous solutions.

H-L-Lys(N3-Gly)-OH is a lysine derivative chemical reagent equipped with an azide group used in click chemistry. This compound can be incorporated into proteins for click modifications.

H-Gly-Gly-Pro-OH (Glycyl-glycyl-L-proline) is a dipeptide composed of glycine and proline, and is an end product of collagen metabolism that is further cleaved by prolidase.

Atrial Natriuretic Peptide (ANP) has the sequence of H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-OH, is a 28 amino acid peptide. ANP is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the hom

H-Gly-Gly-Phe-OH is a tripeptide linker utilized in the synthesis of antibody-drug conjugates (ADC). The N-terminus of the glycine tripeptide is reactive, allowing it to engage in diverse reactions, such as coupling with carboxylic acids or NHS esters.

H-L-Lys(N3-Gly)-OH hydrochloride is a click chemistry reagent featuring an azide group, derived from lysine. This compound can be incorporated into proteins for click modification. It contains an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing alkyne groups. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.