h-gly-gly-gly-oh

H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of three glycine amino acids linked by peptide bonds. It is commonly utilized as a model compound in studies of protein structure and function. Glycylglycylglycine may also act as a neurotransmitter in the central nervous system and has demonstrated antioxidant properties. Furthermore, it holds potential research significance in various diseases, such as cancer, diabetes, and neurodegenerative disorders.

H-Gly-Gly-Phe-OH is a tripeptide linker utilized in the synthesis of antibody-drug conjugates (ADC). The N-terminus of the glycine tripeptide is reactive, allowing it to engage in diverse reactions, such as coupling with carboxylic acids or NHS esters.

H-L-Lys(N3-Gly)-OH hydrochloride is a click chemistry reagent featuring an azide group, derived from lysine. This compound can be incorporated into proteins for click modification. It contains an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing alkyne groups. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.