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gne-0439

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  • Inhibitors & Agonists
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GNE-0439
GNE0439, GNE 0439
T114371241902-40-8
GNE-0439 is a novel, Nav1.7-selective inhibitor with an IC50 of 0.34 uM that also inhibits Nav1.5 (IC50=38.3 uM) and mutant N1742K channels (IC50=0.37 uM), possessing a carboxylic acid group that binds outside the channel pore, distinguishing it from known selective VSD4 binders and making it a valuable tool for ion channel research.
  • $165
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