glutarimide

Glutarimide ,with CAS No. 1121-89-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Glutarimide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Phenyl-glutarimide 4'-oxyacetic-amide-C5-amide-Boc is an E3 ligase ligand-linker conjugate used in the synthesis of PROTACSJ995973.

(S)-Glutarimide-amide-Py-piperidine-CHO is an E3 ligase ligand-linker conjugate, incorporating a CRBN-based ligand and linker, suitable for PROTAC synthesis.

Glutarimide-(1-oxoisoindoline-5-carbaldehyde) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon proteins. It can be connected to target protein ligands via a linker to form a PROTAC.

3,3-Pentamethylene glutarimide is a useful organic compound for research related to life sciences. The catalog number is T65094 and the CAS number is 1130-32-1.

Phenyl-glutarimide 4'-piperazine, a piperazine-functionalized cereblon ligand, facilitates the development of PG-PROTACs with enhanced hydrolytic stability and potency compared to those produced with IMiD (immunomodulatory imide drug) analogs. It serves as a foundation for PROTACDegrader development.

Phenyl-glutarimide 4'-oxyacetic acid, a carboxylic acid-functionalized cerebellar ligand, is utilized in developing PROTAC deactivators due to its superior hydrolytic stability and efficacy. This compound exhibits enhanced binding to PROTAC, [1].

Meletimide (R 5183) is a potent anticholinergic agent that exhibits significant effects on both peripheral and central systems.

3-(4-Chlorophenyl) glutarimide ,with CAS No. 84803-46-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-(4-Chlorophenyl) glutarimide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Histamine glutarimide is a novel small molecule agent functioning as an inhibitor of glutaminyl-peptide cyclotransferase (QPCT), which targets key inflammatory processes including eosinophilic migration and mast cell degranulation, Histamine glutarimide has demonstrated significant anti-asthmatic effects in various preclinical animal models of allergic asthma.

Glutarimide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical.

3,3-Dimethylglutarimide ,with CAS No. 1123-40-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3,3-Dimethylglutarimide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

D-2-Aminoglutarimide is a synthetic intermediate.1It has been used in the synthesis of hydantoins with anti-angiogenic and cancer cell differentiation-inducing activities. 1.Yamaguchi, J., Noguchi-Yachide, T., Sakaguchi, Y., et al.Synthesis of new hydantoins bearing glutarimide or succinimide moiety and their evaluation for cell differentiation-inducing and anti-angiogenic activitiesHeterocycles91(4)764-781(2015)

3, 3 - Tetramethyleneglutarimide also referred to as the TMI (Trimellitic anhydride imide) belongs to the molecular block, is a kind of important raw material for high temperature plastic, It can be used to prepare high temperature resistant polyimide (PI) and polyether imide (PEI) and other high performance materials. It can also be used as an additive to flame retardants to improve the flame retardancy of plastics and coatings.

(S)-Phthalimidinoglutarimide-6-piperazine is the (S)-enantiomer of Phthalimidinoglutarimide-6-piperazine. It acts as an E3 ubiquitin ligase ligand-linker conjugate (E3ligaseligand-linker conjugate). This compound is used in the synthesis of PROTAC SMARCA2 degrader-35.

Phenglutarimide hydrochloride is an anticholinergic. It is used as an antiparkinsonian agent.

Phthalimidinoglutarimide-6-piperazine, a conjugate of E3 ubiquitin ligase ligand-linker, is utilized to synthesize complete PROTACs molecules.

E3 Ligase Ligand-linker Conjugate 88 is composed of Thalidomide and the corresponding linker, forming a conjugate of the E3 ligase ligand and linker (E3 Ligase Ligand-Linker Conjugates). This ligand not only recruits the CRBN protein, serving as an effective ligand for Cereblon, but also plays a key intermediate role in the synthesis of PROTAC molecules.

Phthalimidinoglutarimide-piperidine-NH-Boc, a conjugate of E3 ligase ligand and linker, consists of Thalidomide and the corresponding Linker. It serves as a Cereblon ligand to recruit CRBN protein and acts as a key intermediate for synthesizing complete PROTAC molecules.

Bemegride (3-Ethyl-3-methylglutarimide), a central nervous system stimulant, serves as an antidote for barbiturate poisoning.

Phenglutarimid is an anticholinergic. It is used as an antiparkinsonian agent.

2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12 (2-(2,6-Dioxopiperidin-3-yl)phthalimidine)) is a teratogenic Thalidomide analogue that is more active and significantly more stable against hydrolysis than Thalidomide, enhancing 1,2-dimethylhydrazine-induced rat colon adenocarcinomas [1] [2].

Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.

Actiphenol is a glutarimide antibiotic that exhibits both antifungal and antitumor activity, demonstrating higher potency against pathogens such as coxsackievirus B3, influenza virus A, and herpes simplex virus type 2 than synthetic glutarimide derivatives, and Actiphenol production, along with cycloheximide biosynthesis, is controlled by a single gene cluster encoding an acyltransferase-less type I polyketide synthase in Streptomyces species, highlighting its importance in microbial natural product research.