glutamate decarboxylase a

Glutamate decarboxylase is an enzyme that catalyzes the decarboxylation of glutamic acid to γ-aminobutyric acid (GABA) and carbon dioxide (CO2). Many gut microbes metabolize glutamic acid in a pyridoxal-5′-phosphate (PLP) dependent manner through their glutamate decarboxylase.

L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, i.p.) induces convulsions and decreases GABA concentration throughout the cerebellum, pons, medulla, striatum, cortex, and hippocampus in mice. Chronic administration (3.2 μg/0.5 μl per hour for 13 days) of L-allylglycine in rats increases locomotor activity in an open field test and impairs attention in the 5-choice serial reaction time task (5CSRTT). In vitro, L-allylglycine inhibits GAD only when used at high concentrations (1-80 mM). The more potent in vivo activity can be attributed to metabolic conversion of L-allylglycine to 2-keto-4-pentanoic acid, a more potent convulsant and GAD inhibitor.

Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor for L. monocytogenes and E. coli.

Chelidamic acid is a heterocyclic organic acid with a pyran skeleton and acts as an inhibitor of glutamate decarboxylase, with a Ki of 33 μM.

Allylglycine is a glutamate decarboxylase inhibitor and a GAMMA-AMINOBUTYRIC ACID antagonist. It is used to induce convulsions in experimental animals.

Gabazine free base is a specific antagonist of the GABA receptor. It does not affect GABA-transaminase or glutamate-decarboxylase activities.

GAD65(247-266) epitope TFA, a T cell epitope derived from islet antigens, exhibits competitive binding to the type I diabetes-associated molecule I-A g7, albeit with low affinity. This epitope corresponds to a sequence within Glutamic Acid Decarboxylase 65, an enzyme implicated in the transformation of glutamate into gamma-aminobutyric acid (GABA) [1].

Maleic acid (Standard) is the standard substance of Maleic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of L. monocytogenes and E. coli.