fruiting bodies

Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.

antcin A is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea with strong anti-inflammatory and anti-tumor effects.

Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid isolated from T. titanicus that at a dose of 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin.

Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors.

Ganoderenic Acid K, isolated from the fruiting bodies of Ganoderma lucidum, exhibits potent inhibitory activity against HMG-CoA reductase (HMGCR), demonstrating an IC50 of 16.5 μM [1].

Methyl ganoderate A acetonide, a lanostane triterpene derived from the fruiting bodies of Ganoderma lucidum, serves as a potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 18.35 μM, suggesting potential utility in Alzheimer's disease (AD) research [1].

Hericenone A (compound 6) is an isoindolinone isolated from the fruiting bodies of Hericium erinaceus. At a concentration of 20 μg/mL, Hericenone A effectively inhibits the growth of SMMC-7221 and MHCC-97H cells.

Emeheterone is a natural product from the fresh fruiting bodies of the basidiomycetes Albatrellus confluens.