fr 179642

FR179642 is a key intermediate in the synthesis of the antifungal drug Micafungin and also corresponds to the cyclic peptide core structure of the lipopeptide natural product FR901379. FR179642 belongs to the structural framework of echinocandin-class antifungal compounds and serves as an important reference in the structural optimization and synthesis of β-1,3-glucan synthase inhibitors.

FR179642 is the cyclic peptide nucleus of the lipopeptide antifungal FR901379 and an intermediate in the synthesis of the echinocandin antifungal FK463 .1,2 1.Tomishima, M., Ohki, H., Yamada, A., et al.FK463, a novel water-soluble echinocandin lipopeptide: Synthesis and antifungal activityJ. Antibiot. (Tokyo)52(7)674-676(1999) 2.Ueda, S., Shibata, T., Ito, K., et al.Cloning and expression of the FR901379 acylase gene from Streptomyces sp. no. 6907J. Antibiot. (Tokyo)64(2)169-175(2011)