erythro-sphingosine,

L-erythro-Sphingosine is an L-isomer of sphingosine.

D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator

D-erythro-Sphingosine hydrochloride, also known as Erythrosphingosine, serves as a specific TRPM3 activator and induces retinoblastoma protein dephosphorylation.

GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a sphingolipid with potential applications in research on Parkinson's disease and Lewy body dementia.

C8 Ceramide, a cell-permeable analog, is analog to naturally occur ceramides.

C12-Ceramide (C12 Ceramide (d18:1/12:0)), a ceramide present in the protective membranes surrounding umbilical cord blood vessels in infants born to women with pre-eclampsia, can be used to assess the level of ASM activity in the plasma of patients with Niemann-Pick disease.

C18 Ceramide-1-phosphate (d18:1/18:0) is a long-chain molecule identified in murine skin, promoting the migration of mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells (HUVECs) at concentrations of 0.5 to 5 µM. It exhibits elevated levels in CFPAC-1 pancreatic ductal adenocarcinoma cells compared to pancreatic cancer stem cells, and its myocardial concentration is heightened in Langendorff isolated perfused mouse hearts under an ex vivo ischemia model.

C2 L-erythro Ceramide (d18:1/2:0) is a lipid molecule that can be used in life science related research. The CAS number of C2 L-erythro Ceramide (d18:1/2:0) is 150338-90-2.

C15 Ceramide (d18:1/15:0) is a lipid molecule that can be used in life science related research. The CAS number of C15 Ceramide (d18:1/15:0) is 67492-15-3.

C10 Ceramide (d18:1/10:0) is a lipid molecule that can be used in life science related research. The CAS number of C10 Ceramide (d18:1/10:0) is 111122-57-7.

C32 Ceramide (d18:1/32:0) is a lipid molecule that can be used in life science related research. The CAS number of C32 Ceramide (d18:1/32:0) is 34227-73-1.

C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0) is 890041-50-6.

C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0) is a lipid molecule that can be used in life science related research. The CAS number of C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0) is 34249-41-7.

N-Boc-1-pivaloyl-D-erythro-sphingosine is a reagent used in biochemical reactions.

C6 Ceramide (d18:1/6:0) alkyne is an ω-alkyne derivative of C6 ceramide. The terminal alkyne group enables it to participate in click chemistry reactions, facilitating the labeling of C6 ceramide with fluorescent tags or biotin. This allows for analysis of C6 ceramide's metabolism and biological activity.

Azido-erythro-sphingosine serves as an intermediate for synthesizing lipid molecules with two hydroxyl groups and a terminal azide group. The azide group (N3) can react with alkynes, BCN, and DBCO through click chemistry. Hydroxyl groups may be further derivatized or replaced by other reactive functional groups. Azido-erythro-sphingosine is a derivative of sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets.

Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1-phosphate (d18:1) . In S. cerevisiae, the amount of sphinganine (d20:0) increases 10.8-fold in response to heat stress, indicating it is involved in heat stress adaptation. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers. Sphinganine can block protein kinase C activation in some cases but not others.

C8 Dihydroceramide acts as a negative control for C8 Ceramide, a cell-permeable analog of natural ceramides. C8 Ceramide, also known as N-Octanoyl-D-erythro-sphingosine, exhibits potent chemotherapeutic properties and anti-proliferation effects. Additionally, it stimulates dendritic cells to enhance T cell responses during viral infections. In vitro studies have also shown that C8 Ceramide induces a slight activation of protein kinase (PKC) [4].

Sphinganine 1-phosphate is an intermediate in the sphingolipid metabolic pathway and is structurally similar to sphingosine. It has a protective effect on the kidney and liver through activation of the S1P1 receptor in mice. D-erythro-Dihydrosphingosine 1-phosphate acts as an agonist for S1P4 in Homo sapiens and may activate GPR63 (G protein-coupled receptor), mainly used in the study of Fabry disease, Gaucher disease, Krabbe disease and Leukodystrophy.

C2 Dihydro Ceramide (d18:0/2:0) (C2 Dihydroceramide) is a short-chain ceramide that is a precursor of ceramide synthesis and stimulates ABCA1-mediated cholesterol efflux.

Sphingosine (d18:1), an amino alcohol, is chiefly recognized for its 18-carbon unsaturated hydrocarbon chain. Nevertheless, in mammalian tissues, both sphingosine and its variant, dihydrosphingosine, feature hydrocarbon chains ranging from 12 to 26 carbons. Sphingosine (d15:1) represents a naturally rare variant, serving as an internal standard for chromatographic or spectrometric analyses of sphingoid compounds.

Sphingosine (d16:1), an unconventional sphingolipid, is synthesized through enzymatic reactions starting with the condensation of myristoyl-CoA and serine by serine palmitoyltransferase long-chain base subunit 3 (SPTLC3), which shows a preference for myristoyl-CoA. This compound is found in minute quantities in its free form in human plasma and as a component of various plasma sphingolipids, such as sphingosine-1-phosphate, ceramides, sphingomyelins, and in brain cerebrosides, albeit at lower concentrations than the more common d18:1 sphingoid base. Sphingosine (d16:1) acts as an inhibitor of PKC in mixed micelle assays and diminishes superoxide production triggered by phorbol 12-myristate 13-acetate in isolated human neutrophils, as well as inhibiting the growth of CHO cells with IC50 values of 1 and 3.2 µM, respectively. Additionally, the concentration of sphingolipids containing sphingosine (d16:1) in the plasma is linked to the dietary consumption of saturated fatty acids and protein among ethnic Chinese populations.

N,N-dihexyl Sphingosine (d18:1/6:0/6:0) is a lipid molecule that can be used in life science related research. The CAS number of N,N-dihexyl Sphingosine (d18:1/6:0/6:0) is 2377379-53-6.

C6 Biotin Ceramide (d18:1/6:0) is a lipid molecule that can be used in life science related research. The CAS number of C6 Biotin Ceramide (d18:1/6:0) is 192070-02-3.