ek1sodiumsalt

EK1 sodium salt is a broad-spectrum coronavirus fusion inhibitor that targets the HR1 domain of the viral S protein, blocking fusion between the virus and the host cell membrane and thereby inhibiting viral entry. In vitro, EK1 sodium salt has demonstrated inhibitory activity against a variety of β-coronaviruses and is commonly used in studies of viral infection mechanisms and antiviral drug screening.

EK1 is a peptide-based coronavirus (CoV) fusion inhibitor that exhibits broad-spectrum inhibitory activity against various coronaviruses. EK1 demonstrates significantly enhanced pan-coronavirus fusion inhibitory activity and effectively suppresses SARS-CoV-2. It can form a stable six-helix bundle (6HB) structure with short α-hCoV and long β-hCoV N-terminal heptad repeat sequences.