eca109

Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, exhibiting antinociceptive, anti-inflammatory, and antioxidant activities in different research models.

Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest.

Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1 and decreases STK38 kinase activity. Tanespimycin also downregulated stk38 gene expression.

P-gp inhibitor 29 (41) is a potent inhibitor of P-gp and an apoptosis inducer, with an IC50 value of 8.9 nM in Eca109/VCR cells, making it useful for esophageal cancer research.

Dexylosyltubeimoside III (compound 3) is a cyclic diglycoside isolated from Actinostemma lobatum MAXIM. It exhibits in vitro anticancer activity, inhibiting the growth of human esophageal cancer cell line ECA109 (IC50=22.37 μM), lung cancer cell line A549 (IC50=27.27 μM), and gastric cancer cell line MGC-803 (IC50=36.85 μM).