duocarmycin dm

Duocarmycin DM, a toxin for antibody-drug conjugates (ADCs), functions as a DNA minor-groove alkylator. It exerts its anticancer activity through a distinct curved indole structure combined with a spirocyclopropylcyclohexadienone electrophile [1] [2].

Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.

MA-PEG4-VC-PAB-DMEA-Duocarmycin DM is a drug-linker conjugate for ADC, utilizing the anticancer antibiotic Duocarmycin DM, linked via MA-PEG4-VC-PAB-DMEA [1] [2].

Compound LD-1 (G3-VC-PAB-DMEA-Duocarmycin DM) is a linker molecule based on duocarmycin that is utilized in the preparation of ADCs [1].

Mal-PEG4-VC-PAB-DMEA-duocarmycin-DM is a thiol-reactive Drug-linker. Duocarmycin DM is a DNA alkylating agent that can be used as a toxin for ADC conjugates and is employed in the synthesis of antibody-drug conjugates (ADCs).

Val-Cit-PAB-DEA-Duo-DM is a drug-conjugate compound consisting of the linker Val-Cit-PAB, the spacer DEA, and the ADC toxin Duocarmycin DM (Duo-DM). This compound is utilized in the synthesis of ADC molecules.