dspe-peg(2000)

DSPE-MPEG2000 is a phospholipid–PEG conjugate possessing both hydrophilic and hydrophobic characteristics. DSPE-PEG(2000) is widely utilized in liposome formulation to enhance aqueous dispersion, surface hydration, and in vivo circulation time. DSPE-PEG(2000) supports the development of long-circulating liposomal drug-delivery systems and is frequently applied in preclinical studies involving anticancer and antimalarial therapeutic agents.

DSPE-PEG(2000)-mannose, a pegylated and mannosylated derivative of 1,2-DSPE, has been employed in both in vitro and in vivo studies for delivering peptides, oligodeoxynucleotides, and siRNA via liposomes and lipid nanoparticles (LNPs). Fluorescently labeled LNPs containing DSPE-PEG(2000)-mannose predominantly accumulate in the liver and spleen of mice, significantly more so than in the brain, lungs, heart, kidneys, and pancreas. In immunization studies, liposomes encapsulating Human Papillomavirus type 16 (HPV16) E7 peptides with CpG oligodeoxynucleotides as an adjuvant led to reduced tumor volume and decreased numbers of CD4+ or CD8+ T cells and angiogenesis within tumors in a mouse lung cancer model using TC-1 cells.

DSPE-PEG(2000)-azide is a PEGylated derivative based on 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (1,2-DSPE). This compound is utilized for attaching vascular cell adhesion molecule-1 (VCAM-1) antibodies to vesicles that encapsulate fingolimod, aiming to target the delivery of fingolimod to inflammatory vessels in mouse models simulating post-ischemic neuroinflammation. Additionally, DSPE-PEG(2000)-azide is employed to link fibrinogen mimetic peptides (FMP) to the surface of synthetic platelets used in treating uncontrollable bleeding caused by liver damage in mouse models.

DSPE-PEG(2000)-COOH, a 1,2-distearoyl-sn-glycero-3-PE (DSPE) derivative modified by PEGylation and carboxylation, is a non-toxic and biodegradable amphiphilic copolymer that can be used to form micelles to deliver nanoparticles.

DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.1,2,3DSPE-PEG(2000)-amine has also been used in the synthesis of fluorescein isothiocyanate-loaded mesoporous silica nanoparticles for imaging applications.4It can be conjugated to a variety of functional molecules for improved cellular targeting and uptake of DSPE-PEG(2000)-amine-containing nanoparticles.4,5 1.Sloat, B.R., Sandoval, M.A., Li, D., et al.In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticlesInt. J. Pharm.409(1-2)278-288(2011) 2.Abd-Rabou, A.A., Bharali, D.J., and Mousa, S.A.Taribavirin and 5-fluorouracil-loaded pegylated-lipid nanoparticle synthesis, p38 docking, and antiproliferative effects on MCF-7 breast cancerPharm. Res.35(4)76(2018) 3.Affram, K., Udofot, O., Singh, M., et al.Smart thermosensitive liposomes for effective solid tumor therapy and in vivo imagingPLoS One12(9):e0815116(2017) 4.Wang, L.-S., Wu, L.-C., Lu, S.-Y., et al.Biofunctionalized phospholipid-capped mesoporous silica nanoshuttles for targeted drug delivery: Improved water suspensibility and decreased nonspecific protein bindingACS Nano4(8)4371-4379(2010) 5.Wen, X., Wang, K., Zhao, Z., et al.Brain-targeted delivery of trans-activating transcriptor-conjugated magnetic PLGA/lipid nanoparticlesPLoS One9(9):e106652(2014)

DSPE-PEG(2000)-Amine is a useful organic compound for research related to life sciences and the catalog number is T64566.

DSPE-PEG(2000)-N-Triphenylphosphonium is a functionalized PEG lipid utilized in the synthesis of lipid nanoparticles for drug delivery.

DSPE-PEG(2000)-square is a functionalized PEG lipid utilized in the synthesis of lipid nanoparticles for drug delivery.

DSPE-PEG(2000) Succinyl ammonium is a functionalized PEG lipid suitable for synthesizing lipid nanoparticles used in drug delivery.

DSPE-PEG 2000 is a non-toxic and biodegradable amphiphilic copolymer that can be used to form micelles to deliver nanoparticles.

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

DSPE-PEG-Biotin (MW 2000) is a PEG-based PROTAC linker for PROTAC synthesis.

DSPE-PEG-CH2COOH (MW 2000) is a polyethylene glycol (PEG)-based linker molecule specifically designed for synthesizing protein-targeting chimeras (PROTACs)[1].

DSPE-PEG-OH (MW 2000) is a PEG-based PROTAC linker for PROTAC synthesis.

DSPE-PEG-Maleimide (MW 2000) is a PEG compound which composed of DSPE and maleimide groups. DSPE-PEG-Maleimide (MW 2000) can be used for compose liposomes [1] .

DSPE-PEG Carboxylic Acid Sodium (MW 2000), a PEG-lipid, facilitates the formation of micelle nanoparticles for drug delivery and extends the blood circulation time of liposomes [1].

DSPE-PEG-Azide (MW 2000) has an amphiphilic structure and can form lipid bilayers/micelles in water. It can be used to prepare nanoparticles or liposomes as targeted drug carriers.

DSPE-PEG-SH (MW 2000) is a polyethylene glycol-modified phospholipid with a terminal reactive thiol group capable of forming covalent thioether linkages with Maleimide-containing molecules. DSPE-PEG-SH (MW 2000) self-assembles into amphiphilic lipid bilayers in aqueous solutions and is employed in drug delivery research, including the encapsulation of nucleic acids, peptides, and small molecules, as well as in mRNA vaccine formulations.

DSPE-PEG-Folate, MW 2000 is a folic acid-conjugated PEG (polyethylene glycol) derivative known for its targeting capabilities by binding to folate receptors in cancer cells. It forms micelles/lipid bilayers and is utilized in the study of targeted drug delivery systems.

DSPE-PEG-NHS (MW 2000), is a PEGylated phospholipid derivative containing a reactive N-hydroxysuccinimide (NHS) ester functional group. DSPE-PEG-NHS (MW 2000), is utilized in the fabrication of liposomes and lipid nanoparticles for the encapsulation and delivery of DNA and mRNA vaccines, improving stability, circulation time, and targeting capability of nucleic acid-based therapeutics.

DSPE-PEG-DBCO, MW 2000 is a phospholipid PEG polymer employed to create micelles used for drug delivery in the form of lipid nanoparticles. As a click chemistry reagent, DSPE-PEG-DBCO, MW 2000 contains a DBCO group that can react with molecules containing Azide groups to facilitate a strain-promoted alkyne-azide cycloaddition (SPAAC) reaction.

DSPE-PEG-endo-BCN (MW 2000) is a PEG lipid that enhances the delivery efficiency and tissue specificity of poorly soluble drugs. It is applicable in research focused on drug delivery.

DSPE-PEG-Fluor 594, MW 2000, is a PEGylated lipid that contains a DSPE group and a Fluor 594 fluorescent moiety. DSPE is a type of phospholipid, while Fluor 594 is a red, water-soluble dye.

DSPE-PEG-Fluor 647, MW 2000, is a fluorescent lipid (Ex/Em=648/671 nm) created through the conjugation of a PEG-lipid-dye. DSPE is a type of phospholipid, and Fluor 647 is a fluorescent dye suitable for use in microscopy detection in living organisms.