dimc

Dimethoxycurcumin (Veratrylcurcuminoid) is an analog of curcumin with more metabolical stability. Dimethoxycurcumin induces epigenetic changes in leukemia cells and the expression of promoter methylated genes.

DIM-C-pPhtBu is an orally active endoplasmic reticulum stress activator. It induces mitochondrial and lysosomal dysfunction, excessive mitosis, ROS production, and cell death mediated by the unfolded protein response in cervical cancer cells. DIM-C-pPhtBu exhibits antitumor activity.

DIM-C-pPhOCH3 (C-DIM5) is a Nerve Growth Factor-Induced Bα (NGFI-Bα, Nur77) agonist

DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimics effects of Nur77 RNAi silencing.

DIM-C-pPhCO2Me is an antagonist of nuclear receptor 4A1 (NR4A1).