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By Target- MAO
- mTOR(1)
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Results for "
dihydroevocarpine
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Natural Products2
Dihydroevocarpine
1-methyl-2-tridecylquinolin-4-one
TN109915266-35-0
Dihydroevocarpine (1-methyl-2-tridecylquinolin-4-one) induces AML cytotoxicity, apoptosis and G0 G1 blockade, and inhibits tumor growth by inhibiting mTORC1 2 activity and the mTOR pathway in an acute myeloid leukemia (AML) xenograft model.
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1-Methyl-2-undecyl-4(1H)-quinolone
1-Methyl-2-undecylquinolin-4(1H)-one
TN255359443-02-6
1-Methyl-2-undecyl-4(1H)-quinolone, along with dihydroevocarpine and evodiamine, should serve as chemical markers for the quality control of Evodia rutaecarpa (Juss.) Benth. This compound selectively inhibits type B MAO (MAO-B) activity with an IC(50) value of 15.3 microM using the substrate kynuramine, while not inhibiting type A MAO (MAO-A) activity. It can mitigate high phosphate-induced calcification in human aortic valve interstitial cells (HAVICs) by inhibiting phosphate cotransporter (PiT-1) gene expression and exhibits moderate antiangiogenic activity against human tumor cells.
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