diabetic cardiomyopathy

Regaloside C, a glycerol glucoside isolated from the Lilium genus, exhibits notable anti-inflammatory properties.

AD-9308 is a highly selective, orally active ALDH2 activator. By activating ALDH2, it enhances the clearance of 4-HNE and inhibits myocardial fibrosis, inflammation, and apoptosis. AD-9308 improves mitochondrial function, regulates sarcoplasmic/endoplasmic reticulum calcium transport, and modulates autophagy, thereby restoring intracellular homeostasis. It improves diastolic and systolic dysfunction in diabetic mice and reverses adverse ventricular remodeling. AD-9308 is useful for studying diabetic cardiomyopathy.

FT011, a direct anti-fibrotic agent,attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy.

Fortunellin is a flavonoid isolated from Fortunella margarita (kumquat) that alleviates histopathological heart injury while improving cardiac function by reducing inflammation and oxidative stress in fructose-induced metabolic disease models. Fortunellin decreases pro-inflammatory cytokines and suppresses phosphorylation of IKKα, IκBα, and NF-κB, while upregulating antioxidant defenses including SOD, CAT, HO-1, and activating AMPK/Nrf2 signaling, supporting the use of Fortunellin in research on diabetic cardiomyopathy and cardiometabolic disorders.