dbcopeg4maleimide

DBCO-PEG4-Maleimide is a non-cleavable PEG-based linker used in the synthesis of antibody–drug conjugates (ADCs). DBCO-PEG4-Maleimide contains a dibenzocyclooctyne group, which enables strain-promoted alkyne–azide cycloaddition (SPAAC) with azide-functionalized biomolecules, supporting efficient construction of bioconjugates under copper-free click conditions.

Sulfo DBCO-PEG4-Maleimide is a PEGylated derivative with a maleimide group, commonly used as a linker for synthesizing PROteolysis TAgeting Chimeras (PROTACs)[1].

Sulfo DBCO-PEG4-Maleimide (TEA) is a PROTAC linker that falls under the PEG class. It is utilized in the synthesis of PROTAC molecules. Additionally, Sulfo DBCO-PEG4-Maleimide (TEA) serves as a click chemistry reagent, containing a DBCO group that undergoes a strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.