dbco-maleimide

DBCO-Maleimide (DBCO-MAL) is a non-cleavable ADC linker for the synthesis of ADC compounds.

DBCO-PEG4-Maleimide is a non-cleavable PEG-based linker used in the synthesis of antibody–drug conjugates (ADCs). DBCO-PEG4-Maleimide contains a dibenzocyclooctyne group, which enables strain-promoted alkyne–azide cycloaddition (SPAAC) with azide-functionalized biomolecules, supporting efficient construction of bioconjugates under copper-free click conditions.

Sulfo DBCO-PEG4-Maleimide is a PEGylated derivative with a maleimide group, commonly used as a linker for synthesizing PROteolysis TAgeting Chimeras (PROTACs)[1].

DBCO-NHCO-PEG12-maleimide is a PEG-based PROTAC linker used in the synthesis of PROTACs [1].

DBCO-NHCO-PEG2-maleimide is a polyethylene glycol (PEG) derived PROTAC linker utilized in PROTAC synthesis [1].

DBCO-NHCO-PEG6-maleimide is a polyethylene glycol (PEG)-based linker compound used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Sulfo DBCO-PEG4-Maleimide (TEA) is a PROTAC linker that falls under the PEG class. It is utilized in the synthesis of PROTAC molecules. Additionally, Sulfo DBCO-PEG4-Maleimide (TEA) serves as a click chemistry reagent, containing a DBCO group that undergoes a strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.

DBCO-PEG24-Maleimide, featuring both a maleimide group and a DBCO moiety, is designed for the conjugation of thiol-containing biomolecules and facilitates click chemistry applications with azide-bearing biomolecules [1].

DBCO-PEG-Maleimide (MW 600) (DBCO-PEG-Mal (MW 600)) is a PEG derivative composed of DBCO, polyethylene glycol (PEG) units, and Maleimide. The Maleimide moiety forms stable thioether bonds with thiol groups (-SH). Additionally, the DBCO group in this compound enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.

DBCO-PEG8-Maleimide is a PEG derivative comprised of DBCO, PEG units, and Maleimide. The Maleimide component forms a stable thioether bond with sulfhydryl groups (-SH). The compound contains a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing azide groups.

DBCO-PEG-Maleimide (MW 3400) [DBCO-PEG-Mal (MW 3400)] is a PEG derivative composed of DBCO, PEG units, and Maleimide. The Maleimide group forms a stable thioether bond with thiols (-SH). Additionally, the DBCO group enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules.

DBCO-PEG-Maleimide (MW 400) (DBCO-PEG-Mal (MW 400)) is a PEG derivative composed of DBCO, PEG units, and maleimide. The maleimide group forms a stable thioether bond with thiol groups (-SH). Additionally, the DBCO group in DBCO-PEG-Maleimide (MW 400) enables a strain-promoted alkyne-azide cycloaddition (SPAAC) reaction with molecules containing azide groups.

DBCO-PEG8-amine is a PEG derivative composed of DBCO, PEG units, and an amine (Amine) group. Maleimide forms a stable thioether bond with sulfhydryl groups (-SH). The amine can react with other chemical groups, such as carboxyl and aldehyde groups, to form stable chemical bonds.

DBCO-PEG23-amine is a PEG derivative comprised of DBCO, PEG units, and an amine (Amine) group. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. The amine group can react with other chemical groups (such as carboxyl, aldehyde, etc.) to create stable chemical bonds.

DBCO-PEG3-Maleimide is a PEG derivative composed of DBCO, PEG units, and Maleimide. Maleimide forms stable thioether bonds with thiols (-SH). The DBCO group in DBCO-PEG3-Maleimide enables it to undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.

DBCO-PEG-Maleimide (MW 2000) (DBCO-PEG-Mal (MW 2000)) is a PEG derivative composed of DBCO, PEG units, and Maleimide. The Maleimide moiety forms stable thioether bonds with thiol (-SH) groups. The DBCO group enables the compound to engage in strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with azide-containing molecules.

DBCO-PEG-Maleimide (MW 1000) (DBCO-PEG-Mal (MW 1000)) is a PEG derivative composed of DBCO, PEG units, and maleimide. The maleimide component forms stable thioether bonds with thiol groups (-SH). The DBCO group within this compound can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.

DBCO-PEG-Maleimide (MW 10000) (DBCO-PEG-Mal (MW 10000)) is a PEG derivative composed of DBCO, PEG units, and Maleimide. The Maleimide moiety forms stable thioether bonds with thiol (-SH) groups. This compound contains a DBCO group, allowing it to undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.

DBCO-PEG-Maleimide (MW 5000) (DBCO-PEG-Mal (MW 5000)) is a PEG derivative composed of DBCO, PEG units, and Maleimide. Maleimide forms stable thioether bonds with thiol groups (-SH). The DBCO group in DBCO-PEG-Maleimide (MW 5000) enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.

Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide serves as an ADC linker, utilized in the synthesis of antibody-drug conjugates (ADCs). This compound is a click chemistry reagent, featuring a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.