dbco nhs ester 3

DBCO-NHS ester 3 (Compound 12) is a cleavable linker utilized in the synthesis of antibody-drug conjugate (ADC). It is a derivative of Dibenzylcyclooctyne (DBCO) resulting from the activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent featuring an azide group. It serves as an analog of DBCO-acid, incorporating a PEG linker and a DBCO group. The DBCO group is often utilized in copper-free click reactions due to its high-energy strain. The hydrophilic polyethylene glycol chain and sulfo group enhance its water solubility. The terminal carboxylic acid can react with primary amine groups to form stable amide bonds in the presence of activators such as EDC or HATU. This is a reagent-grade compound intended solely for research purposes.

DBCO-PEG3-NHS ester is a degradable ADC linker that can be used to synthesize antibody-coupled active molecules.

DBCO-NHS ester is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).

3-Azidopropionic Acid Sulfo-NHS Ester is a water-soluble compound containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the p