d109

Hexylcaine HCl also called cyclaine or osmocaine, is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function.

AZD1092 is the glucokinase enzyme activator.

TD1092, a pan-IAP degrader, effectively degrades cIAP1, cIAP2, and XIAP, catalyzing the activation of Caspase 3/7 and fostering apoptosis in cancer cells through IAP degradation. It also obstructs the TNFα-mediated NF-κB pathway, diminishing the phosphorylation of IKK, IkBα, p65, and p38, and operates as a PROTAC. This compound is utilized in cancer research [1].

Quinapril hydrochloride (PD-109452-2) is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and congestive heart failure. Quinapril hydrochloride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury.

PD 109488 is a metabolite of quinapril and is a derivative of Quinapril that acts as an ACE inhibitor. Inhibition of ACE prevents the conversion of signaling peptide angiotensin I into angiotensin II, which acts as a potent vasoconstrictor. Reduced levels of angiotensin II also reduces the amount of aldosterone that is expressed due to RAAS signaling.

L-Phenylalanine-d7 is the deuterated form of L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. It acts as a voltage-dependent α2δ subunit Ca2+ channel antagonist with a Ki of 980 nM. Additionally, L-Phenylalanine is a competitive antagonist at the glycine and glutamate binding sites of NMDARs (KB 573 μM) and non-NMDARs. It is widely used in the production of food flavorings and pharmaceuticals.

Griseofulvin-d3 is the deuterated form of Griseofulvin. Griseofulvin (Gris-PEG; Grifulvin) acts as an antifungal agent.

Isoallolithocholic acid-d4 (3β-Hydroxy-5α-cholanic acid-d4) is a deuterium-labeled form of Isoallolithocholic acid, a derivative of Lithocholic acid. It acts as a T cell modulator by enhancing the differentiation of regulatory T cells (Tregs).

Methyl octanoate-d15 is a deuterated form of Methyl octanoate. Methyl octanoate is a volatile compound that contributes to the aroma of persimmon wine.

L-Serine-2-13C is L-Serine labeled with carbon-13. L-Serine ((-)-Serine; (S)-Serine) is one of the non-essential amino acids that plays a crucial role in cell proliferation.

(±)-1,2-Propanediol-d8 is the deuterium-labeled analogue of (±)-1,2-Propanediol. (±)-1,2-Propanediol, also known as 1,2-(RS)-Propanediol, is an aliphatic alcohol frequently utilized as an excipient in numerous active pharmaceutical formulations to enhance the solubility and stability of active molecules.

Eribulin-d3 (mesylate) is the deuterated form of Eribulin mesylate. Eribulin mesylate, an anti-cancer agent that targets microtubules (microtubule), is utilized for cancer research.

Pitavastatin-d5 (sodium) is the deuterated form of Pitavastatin sodium. Pitavastatin (NK-104) sodium acts as a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase. In HepG2 cells, it inhibits cholesterol synthesis from acetate with an IC50 of 5.8 nM. Pitavastatin sodium is a highly effective inducer of hepatic low-density lipoprotein cholesterol (LDL-C) receptors.

Citric acid-13C6 is a variant of citric acid with carbon-13 isotope labeling. Citric acid, a weak organic tricarboxylic acid, is naturally present in citrus fruits. It functions as a natural preservative and is also commonly used as a food additive.