crbn modulator 1

CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.

Dicyclanil is an insect growth regulator with a chemical structure similar to that of cyclopromazine.

ZXH-1-161 is a potent Cereblon (CRBN) modulator PROTAC that selectively degrades GSPT1 for use in multiple myeloma research.

ZXH-1-161 TFA is a potent small molecule degrader that functions as a modulator of the Cereblon (CRBN) E3 ubiquitin ligase and targets the degradation of the GSPT1 protein, demonstrating anti-tumor potential in multiple myeloma (MM1.S cell line) research. ZXH-1-161 TFA inhibits the STAT3 signaling pathway, effectively suppressing tumor cell proliferation and inducing apoptosis. As an important tool compound in the field of molecular glues, ZXH-1-161 is commonly used in research related to targeted protein degradation and cancer mechanisms.