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By Target- Bcr-Abl
- IAP(1)
- SNIPERs(1)
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Results for "
ciap2:12 nm (ic50)
" in TargetMol Product Catalog- Inhibitors & Agonists2
- PROTAC Products1
SNIPER(ABL)-039
T186902222354-29-0
SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to an LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM for ABL, 10 nM for cIAP1, 12 nM for cIAP2, and 50 nM for XIAP[1].
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Anticancer agent 127
T792472410953-19-2
Anticancer agent 127 (142D6), an IAP inhibitor, covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, with IC50 values of 12 nM, 14 nM, and 9 nM, respectively, demonstrating anticancer effects [1].
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