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chk-1-in-4

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
CHK1-IN-4
T107922120398-41-4
CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.
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1-2 weeks
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FLT3/CHK1-IN-1
T82393
Compound 18, also known as FLT3 CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantly diminishing hERG affinity, with an IC50 of 58.4 μM. It demonstrates efficacy in suppressing tumor growth in mouse xenotransplantation models implanted with MV-4-11 cells [1].
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