cgmp dependent kinase inhibitor peptide acetate

cGMP Dependent Kinase Inhibitor Peptide acetate is a highly selective, ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG/cGKI). cGMP Dependent Kinase Inhibitor Peptide acetate is a synthetically produced peptide with a Ki value of 86 μM. cGMP Dependent Kinase Inhibitor Peptide acetate inhibits PKG-dependent myosin light chain phosphorylation in vascular smooth muscle cells, blocking vasodilatory signaling, and is used in cardiovascular disease research. cGMP Dependent Kinase Inhibitor Peptide acetate also inhibits PfPKG in Plasmodium and Toxoplasma, and is used in antiparasitic research.

Competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by