cereblon ligand-linker conjugates 12

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker, incorporating a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for PROTAC technology applications.

E3LigaseLigand-linker Conjugate 12 is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and its corresponding linker. It functions as a Cereblon ligand to recruit CRBN proteins and serves as a crucial intermediate for the synthesis of complete PROTACs molecules.