bi2536

BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.

BI2536-PEG2-Halo is a bifunctional molecule that integrates a Halo tag ligand with the Polo-like kinase 1 (PLK1) inhibitor BI-2536. This compound selectively exerts cytotoxic effects on mutant p53 cancer cells and inhibits the proliferation of 293T cells expressing the Halo-p53R273H(FL)-mCherry tag, with an IC50 value of 23 nM.

BI-2563 is a small molecule compound with potential antitumor properties. It binds to Polo-like kinase 1 (Plk1) and inhibits its activity, resulting in mitotic arrest, interruption of cell division, and apoptosis in susceptible tumor cell populations. Plk1 is a serine threonine-protein kinase that serves as a key regulator of several critical processes essential for mitosis and cytokinesis.