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Results for "
beta-mca
" in TargetMol Product Catalog- Inhibitors & Agonists2
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- Natural Products1
Mca-SEVNLDAEFK(Dnp)
T868681802078-31-4
Mca-SEVNLDAEFK(Dnp) is a peptide FRET substrate for Beta-secretase 1 (BACE-1), featuring the 'Swedish' Lys-Met Asn-Leu mutation at the β-secretase cleavage site of the amyloid precursor protein (APP). Cleavage at the -Leu-Asp- site of Mca-SEVNLDAEFK(Dnp) releases the highly fluorescent 7-methoxycoumarin (Mca) fragment, which is freed from the quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher, leading to a significantly increased fluorescence intensity that is easily detectable.
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