argyrin a

Argyrin A is a cyclic peptide and potent antitumor agent. It functions by inhibiting the proteasome (proteasome), leading to increased levels of endogenous p27kip1 by preventing protein turnover.

Argyrin D is a naturally occurring cyclic non-ribosomal peptide with significant antibacterial activity against Pseudomonas aeruginosa.

Argyrin C is a natural cyclic nonribosomal peptide that exhibits significant antibacterial activity against Pseudomonas aeruginosa.

Argyrin B is a naturally occurring cyclic peptide that acts as a reversible non-competitive inhibitor of the immunoproteasome. It exhibits higher inhibitory selectivity for the β5i and β1i sites of the immunoproteasome compared to the β5c and β1c sites of the constitutive proteasome, being nearly 20 times more selective for β1i than for its homolog β1c. Additionally, Argyrin B possesses antibacterial properties.

Argyrin F is a cyclopeptide with antitumor properties. It inhibits cell proliferation, migration, invasion, and colony formation by partially inducing apoptosis (apoptosis) and epithelial-mesenchymal transition (EMT). Argyrin F stabilizes p27kip, upregulates p21waf1 cip1, and reduces COX2. Argyrin F is applicable for research in pancreatic ductal adenocarcinoma (PDAC).

Argyrin G is a naturally occurring cyclic nonribosomal peptide.

Argyrin E is a naturally occurring cyclic non-ribosomal peptide.

Argyrin H is a naturally occurring cyclic non-ribosomal peptide.