ard 61

ARD-61 is a potent and specific PROTAC androgen receptor (AR) degrader, exhibiting high effectiveness. It effectively induces the degradation of AR and progesterone receptors (PR) in AR+ cancer cell lines, leading to apoptosis. Additionally, ARD-61 demonstrates significant tumor growth inhibition in the MDA-MB-453 xenograft model in mice.

Boc-bipiperidine-ethynylbenzoic acid is an alkyl/ether-based PROTAC linker frequently used in the synthesis of ARD-61.

PROTAC PTK6 ligand-1 is a functional intermediate used in the preparation of BTK kinase inhibitors and serves as a key synthetic building block for proteolysis-targeting chimera development, including the synthesis of ARD-61, PROTAC PTK6 ligand-1 enables targeted protein degradation studies and facilitating advanced medicinal chemistry research focused on kinase-driven disease models.