antiparasitic agent-4

Antiparasitic agent-4 (compound 4q) exhibits high antiparasitic activity with an IC50 of 8.51 μM for Leishmania infantum (L. infantum) and an IC50 of 2.20 μM for Trypanosoma cruzi (T. cruzi). It is also cytotoxic against HepG2 cells with a CC50 of 18.97 μM [1].

T.cruzi-IN-4 (Compound 21) is an antiparasitic agent. It suppresses both the trypomastigote and amastigote forms of Trypanosoma cruzi, achieving an IC50 of 0.033 μM (after 120 hours). Additionally, T.cruzi-IN-4 hinders the promastigote and amastigote forms of Leishmania infantum, with IC50 values of 28.74 and 61.82 μM respectively, and it inhibits the promastigote form of Leishmania amazonensis with an IC50 of 18.38 μM.

Antiviral agent 17 (Compound 4) is an anti-infection compound with strong antiviral effects, demonstrated by an EC50 of 0.015 μM in a human replicon assay, and effective against murine norovirus. It has potential applications in studying infectious and malignant diseases[1].

Anti-infective agent 3 is an antiprotozoal and antimycobacterial agent. Anti-infective agent 3 (compound 3l) exhibits antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC 50 values of 0.47 and 0.13 μM, respectively. Anti-infective agent 3 exhibits antimycobacterial activity against Mycobacterium smegmatis with a MIC of 4 μg/mL [1].